Synthesis of New 1,3-indandione Derivatives

264 Substituted 1,3-indandione derivatives have shown a large applicability during the last three decades in the fields of medicine [1-5], biology [6,7] and agriculture [8]. There are many references related to the biological activity of some 2-substituted indan-1,3-dione derivatives such as their good anticoagulant [9], anti-inflammatory [10], analgezic [11], antibacterial [12] or bronchiadilating [13] activities. Taking into consideration the high frequency of embolism or arterosclerosis related diseases, study of 1,3-indandione derivatives aims at finding new potential biologically active compounds. Recently, compounds containing the indandione moiety were reported as inhibitors of human papilloma virus type 11 [14] or inhibitors of aromatase (indanopiridazine), an enzyme involved in estrogens biosynthesis 15]. Some indanopyridazines have also been tested and reported as inhibitors of monoaminoxidase B, which is an enzyme involved in Alzheimer disease [16]. Moreover, 1,3-indandione derivatives may find uses as dyes having a similar structure to indigo-based dyes as well as intermediates in the manufacture of dyes [1719]. More recent papers describe new potentially biological active compounds containing the indanedione ring which have as intermediates 2-aryliden-1,3-indandiones [20,21]. Taking into account that many of the biologically active compounds derived from 1,3-indandione are 2substituted derivatives or have as intermediates such derivatives, the present paper focuses on synthesis of such 2-substituted compounds.